THESIS ON SCRUB TYPHUS

Scrub typhus in Uttarakhand, India: The most widely performed laboratory test in India is Weil-Felix test which has low sensitivity and specificity. A study was conducted in Delhi among the febrile paediatric patients which did not have definitive diagnosis. First case of scrub typhus with meningoencephalitis from Kerala: Find articles by Suryanarayana Bettadpura Shamanna. The infection is transmitted by bite of larval stage chiggers of mites belonging to the family Trombiculidae. The patients age varied from 10 months to 80 years were taken for the study.

Scrub typhus being the re-emerging zoonosis is increasingly recognised in India. Find articles by Chanaveerappa Bammigatti. The organism is also extremely dangerous requiring BSL—III facility for its culture which is impractical in most laboratories in India [ 15 ]. Outbreak of scrub typhus in the North East Himalayan region-Sikkim: Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order. Open in a separate window.

The preferential site of mite bite where the eschar is formed mostly in the intertriginous surfaces axilla, scrotum, perianal region which can be easily overlooked by the doctors [ 16 ].

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

National Center for Biotechnology InformationU. Nested PCR for detection of 56 kDa gene specific for Orientia tsutsugamushi with good sensitivity of and specificity may be recommended in laboratories with molecular lab facility [ 14 ]. The drawback of serology test is that the advantage of testing directly the presence of organism is not possible [ 14 ].

Outbreak of scrub typhus in the North East Himalayan region-Sikkim: High-level expression of a kilodalton protein gene bor56 of Rickettsia tsutsugamushi Boryong and its application to enzyme-linked immunosorbent assays.

  ESSAY ON MERE SAPNO KA BHARAT IN 250 WORDS

In our study single time point estimation is done, which is a major drawback. Diagnosis of scrub typhus. The organism is also extremely dangerous requiring BSL—III facility for its culture which is impractical in most laboratories in India [ 15 ].

Investigation of an outbreak of scrub typhus in the himalayan region of India. InKim et al.

thesis on scrub typhus

Is scrub typhus a cause of febrile illness among paediatric population of delhi? In a study by Sharma et al. Evaluation of tests for serological diagnosis of scrub typhus. The current gold standard is imperfect as it is expensive requiring a fluorescence microscope.

thesis on scrub typhus

Ann Indian Acad Neurol. The cut-off value was obtained by calculating the average of optical density OD plus three times of standard deviation SD from serum samples of healthy individuals. A prospective study on distribution of eschar in patients suspected of scrub typhus. Scrub typhus has been one of the most covert emerging and re-emerging Rickettsial infections with increasing trend in incidences of the disease worldwide including India.

Molecular diagnosis of scrub typhus: Conclusion The medical fraternity needs to understand the pitfalls of currently available Weil-Felix test which is still common in India and must include tests with better performance like IgM ELISA and nested PCR in the diagnostic algorithm of scrub typhus to reduce the burden of the disease.

Scrub typhus in patients reporting with acute febrile illness at a tertiary health care institution in Goa.

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

The study was conducted only after obtaining written informed consent from the patients. It is a prospective study which was carried out between January to June 3 years 6 monthsin a tertiary care hospital in Puducherry, South India.

  OPBOUW MASTER THESIS UTWENTE

The disease is also transmitted from larval stage of mites to rats, where man is an accidental host. Scrub typhus, a zoonotic disease is one of the most covert emerging and re-emerging Rickettsial infections.

Therefore it is recommended to perform both pathogen and antibody based tests. scru

The clinical symptoms are fever, headache, myalgia, malaise, rash and lymphadenopathy which are commonly seen in other acute febrile illness like malaria, enteric fever, leptospirosis, dengue etc. Though it is rationally considered as disease found in rural areas, it is also well described from urban ytphus like Delhi and Chennai infecting people, as the tiny mite islands are seen in the vegetation around the dwellings. Typhus fever in Pondicherry.

Expert Rev Anti Infect Ther. J Clin Diagn Res. The IgM ELISA with good sensitivity and specificity, ease to perform, swift results and also suitable for testing large number of specimens may ln considered as good replacement for Weil-Felix test and Thesus test in diagnosis of scrub typhus.

The most widely performed laboratory test in India is Weil-Felix test which has low sensitivity and specificity. After screening patients with acute febrile illness with a battery of diagnostic tests such as Para F for malaria, Widal tests, ICT for dengue and Ig M ELISA for leptospirosis, 63 samples reacted positively for above mentioned tests and were excluded.